While every effort has been made to describe these plants accurately, please keep in mind that height, bloom time, and color may differ in various climates. These abundant of phenolic compounds were proven to have the capabilities in regulating cell proliferation and death pathways including cell growth, inhibition of kinase activity, induction of apoptosis, and suppression of matrix metalloproteinases secretion (Guimarães et al., 2013). (2016) reported that lower curcumin-to-lipid ratio for PEGylated liposomes could increase its stability in plasma and bioavailability to pancreatic adenocarcinoma cells. Origanum onites, Satureja thymbra, Coridothymus capitatus, Origanum dictamnus were also investigated.185–187, The water-soluble fraction of the methanol extract of oregano leaves was purified with polyamide chromatography to give five polar compounds188,189–rosmarinic acid, caffeic acid, protocatechuic acid 61, a new glucoside of protocatechuic acid 62, and a derivative of rosmarinic acid, 2-caffeoyloxy- 3-[2-(4-hydroxybenzyl)-4,5-dihydroxy]phenylpropionic acid 63. Antioxidants protect the aerial parts of plants from damage due to cold. However, the solubility of PTX is very low (roughly 0.7–30 µg/mL). Mountain tea and Dictamnus are two representative Mediterranean herbs which are consumed mainly as infusions. These two depsides (25 and 26) were also identified and reported from another close species M. vexator (false jaboticaba) in 2012 (Dastmalchi, Flores, Wu, Ma, & Dabo, 2012). Acyclic monoterpenes are derivatives of 2,6 dimethyloctane, and most commonly identified in plant sources are: geraniol, linalool, ocimene, myrcene, aloocimene, nerol, citronellol, etc. The effect of low temperature on plant systems is one of the most severe stress factors; it affects developmental processes, productivity, diversity, and distribution in a broad spectrum of ways (Chinnusamy et al., 2007; Rahman, 2013). The method of reversed phase HPLC coupled with a UV-vis multiwavelength detector has been used for the determination of herb polyphenols. Along with essential oils, extracts have proved to be rich in terpene core compounds as well: dichloromethane extracts of some Lamiaceae members collected in Turkey were rich in different terpene compounds. Antitumor effect found in herbal infusions was suggested to be attributed by the presence of phenolic content and other phytochemicals. β-Phellandrene along with sabinene, α-bisabolol, and α-phellandrene was major constituent of the essential oil of yet another member of Apiaceae family, Selinum sp. A 2-hydroxypropyl-γ-cyclodextrin/curcumin liposome considerably showed anticancer ability against osteosarcoma and breast cancer (Dhule et al., 2012). (Pereira et al., 2018). Monoterpenes are widely distributed in the Plant Kingdom, especially in the following families: Asteraceae, Apiaceae, Lamiaceae (in the scope of this chapter), but may also be identified in plants belonging to other families such as: Myrtaceae, Lauraceae, Rutaceae, Poaceae, and Cupressaceae. The liposome increases the therapeutic potential of the drug by enhancing its half-life, absorption, and bioavailability inside the body. The leaves of a plant growing in Crete and Candy were used by the Ancients for wounds, and it is still known as Dictamnus or Dittany of Crete, being Origanum Dictamnus … Paclitaxel (PTX) is a vital phytomedicine which has anticancer activity against carcinoma of breast, ovary, colon, lung, esophagus, blood, urinary tract, head, and neck (Spencer and Faulds, 1994). Thymol was a better antioxidant in triacylglycerols of sunflower oil (TGSO) than in triacylglycerols of lard (TGL). Studies were also done to synthesize liposome from other lipids. Cholesterol can attach with other stabilizing molecules such as polyethylene glycol (PEG) for construction of “stealth liposomes” (Immordino et al., 2006). The liposome can prepare with synthetic and natural lipids molecules. Heinonen, in Antioxidants in Food, 2001, Oregano is very often used as a spice and its flavour is very popular with consumers all over the world. Whereas both camphor and pinene are important allelopathic agents (identified in Salvia leucophylla Greene—Asteraceae). Liposomes are bilayer membranous structure of amphiphilic lipids (Zhang and Granick, 2006). … et Heldr., Salvia rosifolia Sm., and Rosmarinus officinalis L. (Lamiaceae) (Zuzarte & Salgueiro, 2015). It has been used from ancient times against stomach pains, and as an effective painkiller and wound-healing agent. Dittany of Crete is a famous medicinal plant since ancient times. Amaracus tomentosus Moench Dictamnus creticus Garsault nom. In summary, jaboticabin was synthesized from commercially available phloroglucinol and 3,4-dihydroxybenzoic acid in nine linear steps (Wu et al., 2013). Of phosphatidylserine into liposomes can increase the entrapment of PTX into the delivery of drugs to charged! Ovarian carcinomas in water and susceptible to oxidation as well as unstable at high temperatures was found in Crete secretion! 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